The introduction of midi-chlorians in the Star Wars prequels hasn't been welcomed with open arms considering that it somehow changed Force mythology. However, it looks like George Lucas had invented the mysterious cells when he was still working on the first Star Wars movie.
According to ScreenRant, Lucas had actually come up with the idea of cells in someone's body being the reason why they can connect to the Force. There are some details on the subject in the J.W. Rinzler book The Making of Star Wars: The Definitive Story Behind The Original Film. The book contains Lucas' notes from 1977 offering a lot of information about everything Star Wars. Interestingly, it contains a section about how someone can be called "strong in the Force."
An excerpt from the book reads as follows:
"It is said that certain creatures are born with a higher awareness of the Force than humans. Their brains are different; they have more midi-chlorians in their cells."
It's interesting that Lucas never brought up the subject of midi-chlorians in the original trilogy but decided to save the explanation in the prequels. It might make sense, considering that the original films only featured two Jedi who were too busy training Luke Skywalker to discuss cells. Lucas may have reserved the information so that a person like Qui-Gon Jinn could explain it to a young Anakin Skywalker in the prequels.
It's still unclear if the subject of midi-chlorians will be brought up again in the current trilogy. We might be in for a surprise when Star Wars: Episode IX finally premieres on December 20, 2019.
Related: Star Wars: Episode IX Could Rewrite Rey's Lineage, Kylo Ren's TLJ Reveal To Be Retconned
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