Star Wars creator George Lucas has toyed with the idea of midi-chlorians for years now. In 1977, Lucas noted in the guidelines for the Expanded Universe that certain creatures are born with a “higher awareness” of the Force than that of humans. Their brains are different in the way that they have more midi-chlorians in their cells. The sequel trilogy has added a scientific factor to the concept, wherein microscopic life forms exist within all living beings and that these allow hosts to commune with the Force.
As noted by ScreenRant, Disney has been trying to redeem Lucas’ “maligned” prequel trilogy, though they haven’t completely explored the concept of midi-chlorians. That being said, the Secrets of the Jedi book seemingly draws the line, basically dismissing midi-chlorians as irrelevant.
The book is said to be based on the fictional notes of Luke Skywalker, completed before his death in The Last Jedi. In one section of the book, Luke says the Jedi “used science” to explain why some feel the Force strongly than others. “Prospective younglings were tested by the Jedi Order for midi-chlorians - microscopic life-forms that reside in all living cells and impart the will of the Force to their hosts,” the section reads. “Those with a higher number of midi-chlorians were able to hear the will of the Force more clearly than others.”
“Personally, I've never been one to worry about how exactly the Force whispers to me,” Luke wrote. “All that matters to me is that it still does."
The Phantom Menace showed how powerful Anakin could be through midi-chlorians, with his count much higher than anyone else’s. Basically, Luke’s dismissive remarks show that Lucasfilm maybe doesn’t feel the need to explore midi-chlorians. That it doesn’t matter how the Force works, as long as it still does.
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